|James F. Curran||@|
|Professor and Chair of the Biology Department
B.A., University of Delaware
108 Winston Hall
Areas of Interest
Molecular Mechanisms of Protein Synthesis, Gene Regulation, Nucleic Acid Chemistry, Microbial Evolutionary Mechanisms
The ribosomal translation of the genetic code is a fundamental biological process. Cells are composed mostly of protein, and cellular well-being depends on the accurate and efficient production of that biomass. We have ongoing projects that explore the molecular mechanisms of programmed frameshifting, the function of the ribosomal exit site, and the evolution of the genetic code.
I'm also a research consultant for the NIH.
| Courses Taught
Microbiology, Genetics, Biochemistry, Molecular Biology, Microbial Pathogenesis and various graduate seminars in the molecular biosciences including gene expression, protein synthesis, the molecular biology of RNA, "molecular fossils," and molecular modeling. I also teach freshman seminars; one on the human genome, another on how biological and geographical factors have influenced human history, and a third on social and economic issues facing humanity in the 21st century.
Sanders, C.L., Lohr, K.J., Gambill, H.L, Curran, R.B. and Curran, J.F. 2008. Anticodon loop mutations perturb reading frame maintenance by the E site tRNA. RNA, 1874-1881.
Sanders, C.L. and Curran, J.F. 2007. Genetic analysis of the E site during RF2 programmed frameshifting. RNA 13, 1483-1491..
Lim, V.I., Curran, J.F. and Garber, M. 2005. Ribosomal elongation cycle: Energetic, Kinetic and Stereochemical aspects, Journal of Molecular Biology 351: 470-480.
Curran, J.F. 2003. Death, Taxes, and the Genetic Code? Chemistry & Biology 10:1-2.
Wu, L., and Curran, J.F. 1999. An allosteric synthetic DNA. Nucleic Acids Research 27: 1512-1516.
Tsai, F., and Curran, J.F. 1998. tRNA2Gln mutants that translate the CGA arginine codon as glutamine in Escherichia coli. RNA 4: 1514-1522.
Curran, J.F. 1998. Modified Nucleosides in Translation, chapter 27 in Modification and Editing of RNA: The Alteration of RNA Structure and Function, H. Grosjean, and R. Benne, eds. American Society for Microbiology Press, pp. 493-516.
Qian, Q., Curran, J.F., and Bjork, G.R. 1998. The N6-methyl group of the modified nucleoside N6-methyl-N6-threonylcarbamoyladenosine (m6t6A) in transfer RNA of Escherichia coli improves translational efficiency, Journal of Bacteriology 180: 1808-1813.
Li, J.-n., Esberg, B, Curran, J.F., and Bjork, G.R. 1997. Three modified nucleosides present in the anticodon stem and loop influence the in vivo aa-tRNA selection in a tRNA-dependent manner. Journal of Molecular Biology 271: 209-221.
Schwartz, R. and Curran, J.F. 1997. Analyses of frameshifting at UUU-pyrimidine sites, Nucleic Acids Research 25, 2005-2011.
Curran, J.F. and Yarus, M. 1987. Reading frame selection and tRNA anticodon loop stacking. Science 238, 1545-1550.
Recent Op-Ed Articles:
Return to list of Biology Faculty