Chen Liu

207 Olin Physical Lab,WFU,Winston Salem, NC 27109                                                                                          liuc9@wfu.edu


EDUCATION

Wake Forest University, Department of Physics, Winston-Salem, NC
Ph.D., Physics     (Specialty in Biophysics)                                                                          Aug 2013
Wake Forest University, Schools of Business, Winston-Salem, NC
Master of Business Administration                                                                                       Aug 2013
Bowling Green State University, Bowling Green, OH
Master of Science in Physics, GPA: 3.9                                                                               Aug 2009
Thesis: A numerical and analytical study of phonation threshold pressure
and experiments with a physical model of the vocal fold mucosa                                                                                         
East China University of Science and Technology, Shanghai, China
Bachelor of Science in Physics, GPA: 3.3                                                                             Jun 2007
Thesis: A numerical calculation of the state energy of fractional quantum
hall effect in the Haldane’s model                                                                                                                            


RESEARCH EXPERIENCE

Simulations of chemical and biological reactions of reactive oxygen species in cellular mechanism
Used computational modeling to solve biologically relevant differential equations.
The effect of microparticles (MPs) on Nitric Oxide (NO)-mediated vasodilation with and without intravascular flow on rat mesenteries in myograph
Conducted on single arteriole blood vessels examining vasodilation.
Plasma NO-scavenging activity
Examined NO-scavenging activity of plasma derived from various ages of banked blood on a NO analyzer
Simulations of NO uptake by red blood cells (RBC) and by MPs derived from red cells
Confirmed extracellular diffusion of NO limits NO uptake rate and discovered microparticle encapsulated Hemoglobin (MP-HbA) reduce NO bioactivity significantly on a COMSOL model
Stopped-flow absorption measurements of NO uptake by red blood cells under oxygenated and deoxygenated conditions with a viscous or non-viscous buffer
Demonstrated the viscosity of the buffer had a substantial effect on external diffusion using millisecond-resolved kinetics
Kinetics of Nitric Oxide reactivity with MP-HbA
Discovered MP-HbA scavenges NO 2.5 to 3 times slower than free HbA but 1000 times faster than RBC-HbA by using fast time-resolved flash photolysis technique


PUBLICATIONS

LEADERSHIP