Wake Forest University
Winston-Salem, NC 27109
215 Olin Physical Laboratory
213 Olin Physical Laboratory
Research in the Macosko group is focused
on understanding the mechanics of protein machines. We use techniques, including
atomic force microscopy (AFM), single molecule fluorescence microscopy
and motion-enhanced differential interference contrast light microscopy (MEDIC), to
study how protein motors use chemical fuel to power their work cycle. One of
our strategies in this effort is to use force and temperature to slow down or speed up
of the motors. This gives us information about the potential energy surface
corresponding to the rate limiting mechanical transition in the molecular motor.
Our long-term goal is the identification of precise mechanical-chemical couplings
in molecular machines and the characterization of the overall pathways of their
(For details on projects, see Research.)
thermodynamics, biophysics, protein structure and function.
on WFU courses, see Teaching.)
Graduate and undergraduate research projects for
biophysics, biochemistry, or structural biology can be found in my
laboratory. Students can study the relationship between structure,
chemical activity, and mechanical motion of a particular protein machine or
family of protein motors. Molecular motors in the kinesin family are of particular
interest. Students can use a number of different techniques to study these motors,
such as MEDIC or AFM in combination with single molecule fluorescence,
microscopy with FRET (fluorescence resonance energy transfer). If you are
please contact me.
Blurb from the Physics Department's welcome
"The Wake Forest University Department of Physics is delighted to welcome its newest faculty member, Jed Macosko. Jed comes to us from the University of New Mexico. He received his B.S. from MIT and his Ph.D. from UC-Berkeley. Dr. Macosko studies protein motors and machines, mapping their potential energy surfaces. Surveying and mapping the potential energy surfaces of protein machines is essential for understanding their function and for developing drugs to halt their activity. Dr. Macosko wowed the department with his exceptional demonstration of teaching during his interview here."
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