Macosko Lab


  1. Mechanical properties of normal versus cancerous breast cells. Smelser AM, Macosko JC, O'Dell AP, Smyre S, Bonin K & Holzwarth G. Biomechanics and Modeling in Mechanobiology. [Epub ahead of print] (2015) Link to Paper
  2. Force-velocity relationship for multiple kinesin motors pulling a magnetic bead. Fallesen TL, Macosko JC & Holzwarth G. European Biophys. Journal 40:1071-79 (2011)Link to Paper
  3. Measuring the number and spacing of molecular motors propelling a gliding microtubule. Fallesen TL, Macosko JC & Holzwarth G. Phys Rev E Stat Nonlin Soft Matter Phys. 83, 011918 (2011)Link to Paper
  4. Magnet polepiece design for uniform magnetic force on superparamagnetic beads. Fallesen T, Hill DB, Steen M, Macosko JC, Bonin K & Holzwarth G. Rev Sci Instrum. 81:074303. (2010)Link to Paper
  5. Selection of Bead-Displayed, PNA-encoded Chemicals. Gassman NR, Nelli JP, Dutta S, Kuhn AM, Bonin KD, Guthold M & Macosko JC. Journal of Molecular Recognition 23:414-422 (2010)Link to Paper
  6. Kinesin velocity increases with the number of motors pulling a viscoelastic load. Gagliano JM, Walb MC, Blaker BD, Macosko JC & Holzwarth G. Eur. Biophys Journal 39:801-13 (2009)Link to Paper
  7. In vivo Multimotor Force-Velocity Curves by Tracking and Sizing Sub-Diffraction Limited Vesicles. Shtridelman Y, Holzwarth GM, Bauer CT, Gassman NR, DeWitt DA & Macosko JC Cellular and Molecular Bioengineering, 2: 190-199 (2009)Link to Paper
  8. In silico evidence for functional specialization after genome duplication in yeast. Turunen, O., Seelke, R., & Macosko, J.C. FEMS Yeast Res. 9: 16-31 (2009)Link to Paper
  9. The Genetic Code—more than just a table. Berleant D., White M., Pierce E., Tudoreanu E., Boeszoermenyi A., Shtridelman Y., and Macosko J.C. Cell Biochem Biophys., 55: 107-116(2009)Link to Paper
  10. Macosko J.C., Johnson A.D., & Yocum S.M., “Outside the Business School, Teaching Entrepreneurship through Teams and Projects: Three Case Studies” Edward Elgar Publishing ISBN: 978 1 84720 455 4 (August, 2009)
  11. Intraneuronal vesicular organelle transport changes with cell population density in vitro. Bauer CT, Shtridelman Y, Tome CM, Grim JQ, Turner CP, Tytell M & Macosko JC Neurosci Lett. 441: 173-177 (2008)Link to Paper
  12. Motion-enhanced, differential interference contrast (MEDIC) microscopy of moving vesicles in live cells: VE-DIC updated. Hill DB, Macosko JC & Holzwarth G J Microsc 231: 433-439 (2008)Link to Paper
  13. Force-Velocity Curves of Motor Proteins Cooperating In Vivo. Shtridelman Y, Cahyuti T, Townsend B, Dewitt D & Macosko JC Cell Biochem Biophys 52:19-29 (2008)Link to Paper
  14. Fewer active motors per vesicle may explain slowed vesicle transport in chick motoneurons after three days in vitro. Macosko, J.C., Newbern, J.M., Rockford, J., Chisena, E.N., Brown, C.M., Holzwarth, G., and Milligan C.E. Brain Res. May 23, 2008; 1211: 6–12.Link to Paper
  15. Speckled microtubules improve tracking in motor-protein gliding assays.Chisena, E.N. Wall, R.A., Macosko, J.C., and Holzwarth, G. Physical Biology, 4, 10-5 (2007)Link to Paper
  16. Stepping Statistics of Single HIV-1 Reverse Transcriptase Molecules during DNA Polymerization Ortiz, T.P., Marshall, J.A., Meyer, L.A., Davis, R.W., Macosko, J.C., Hatch, J., Keller, D.J. & Brozik, J.A. Journal of Physical Chemistry B 109,16127 – 16131 (2005)Link to Paper
  17. Closing of the Fingers Domain Generates Motor Forces in the HIV Reverse Transcriptase. Lu, H., Macosko, J.C., Habel-Rodriguez, D., Keller, R.W., Brozik, J.A. & Keller, D.J. Journal Biological Chemistry 24, 54529-54532 (2004)Link to Paper
  18. Huntingtin spheroids and protofibrils as precursors in polyglutamine fibrilization. Poirier, M.A., Li H., Macosko, J.C., Cai, S., Amzel, M., Ross, C.A., Journal of Biological Chemistry. 43, 41032-41037. (2002)Link to Paper
  19. The 1-127 HA2 construct of influenza virus hemagglutinin induces cell-cell hemifusion. Leikina E., LeDuc D.L., Macosko J.C. Epand, R., Epand, R., Shin ,Y.K., Chernomordik, L.V., Biochemistry 40, 8378-8386 (2001).Link to Paper
  20. 15N NMR study of the ionization properties of the influenza virus fusion peptide in zwitterionic phospholipid dispersions. Zhou Z., Macosko J.C., Hughes, D.W., Sayer, B.G., Hawes, J., Epand, R.M..Biophysical Journal 78, 2418-2425 (2000).Link to Paper
  21. A novel 5' displacement spin-labeling technique for electron paramagnetic resonance spectroscopy of RNA. Macosko, J.C., Pio, M.S., Tinoco, I. Jr, Shin, Y.K. RNA Journal 9, 1158-1166 (1999).Link to Paper
  22. The ectodomain of HA2 of influenza virus promotes rapid pH dependent membrane fusion. Epand, R.F., Macosko, J.C., Russell, C.J., Shin, Y.K., Epand, R.M. Journal of Molecular Biology 286, 489-503 (1999).Link to Paper
  23. The synaptic SNARE complex is a parallel four-stranded helical bundle. Poirier, M.A., Xiao, W., Macosko, J.C., Chan, C., Shin ,Y.K., Bennett, M.K. Nature Strucural. Biology 5, 765-769 (1998).Link to Paper
  24. The mechanism for low-pH-induced clustering of phospholipid vesicles carrying the HA2 ectodomain of influenza hemagglutinin. Kim CH, Macosko JC, Shin YK. Biochemistry 37:137-144 (1998).Link to Paper
  25. The membrane topology of the fusion peptide region of influenza hemagglutinin determined by spin-labeling EPR. Macosko, J.C., Kim, C.H., Shin. Y.K. Journal of Molecular Biology 267:1139-1148 (1997).Link to Paper
  26. On the dynamics and conformation of the HA2 domain of the influenza virus hemagglutinin. Kim, C.H., Macosko, Yu, Y.G., Shin, Y.K. Biochemistry 35:5359- 5365 (1996).Link to Paper


  1. Guthold, Martin, and Jed C. Macosko. Compositions, Methods, and Kits for Identifying Candidate Molecules from Encoded Chemical Libraries. Wake Forest University, assignee. Patent US 8741558 B2. 3 June. 2014.
  2. Bonin, Keith, Jed C. Macosko, Jason Gagliano, Martin Guthold, and Roger Cubicciotti. Integrated Compound Discovery Systems and Methods. Wake Forest University Health Sciences, Nanomedica Llc, assignee. Patent WO2013096777 A3. 15 Aug. 2013.